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Yoshimasa Yamaguchi Selected Research

spiro(imidazo- (1,2- a)pyridine- 3,2- indan)- 2(3H)- one

2/2016Potentiation of Acetylcholine-Mediated Facilitation of Inhibitory Synaptic Transmission by an Azaindolizione Derivative, ZSET1446 (ST101), in the Rat Hippocampus.
1/2013Combination effects of ZSET1446/ST101 with memantine on cognitive function and extracellular acetylcholine in the hippocampus.
1/2012Effects of ZSET1446/ST101 on cognitive deficits and amyloid β deposition in the senescence accelerated prone mouse brain.
7/2008Spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) treatment rescues olfactory bulbectomy-induced memory impairment by activating Ca2+/calmodulin kinase II and protein kinase C in mouse hippocampus.
6/2006Effects of a novel cognitive enhancer, spiro[imidazo-[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446), on learning impairments induced by amyloid-beta1-40 in the rat.

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Yoshimasa Yamaguchi Research Topics

Disease

3Alzheimer Disease (Alzheimer's Disease)
02/2016 - 08/2002
3Cognitive Dysfunction
01/2013 - 06/2006
2Memory Disorders (Memory Loss)
07/2008 - 06/2006
1Fatigue
11/2008
1Neoplasms (Cancer)
11/2008

Drug/Important Bio-Agent (IBA)

5spiro(imidazo- (1,2- a)pyridine- 3,2- indan)- 2(3H)- oneIBA
02/2016 - 06/2006
2indanIBA
02/2016 - 07/2008
2pyridineIBA
02/2016 - 07/2008
2Amyloid beta-PeptidesIBA
01/2012 - 06/2006
2Nootropic Agents (Nootropics)IBA
01/2012 - 07/2008
1Scopolamine (Hyoscine)FDA Link
01/2013
1MetalsIBA
11/2008
1TitaniumIBA
11/2008
1Cholinergic Agents (Cholinergics)IBA
06/2006
1(3,3- dibenzylimidazo(1,2- a)pyridin- 2- (3H)- one)IBA
08/2002

Therapy/Procedure

1Mandibular Osteotomy
11/2008
1Lasers (Laser)
11/2008
1Oral Administration
07/2008